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What Is Semaglutide Injection (Weight Loss Shot)? Who Is It Suitable For? How Is It Used? What Are the Side Effects?

Created18.08.2026 15:48:57
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Last Updated18.08.2026 16:02:21
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Medical Review18.08.2026
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In this article titled “What Is Semaglutide Injection (Weight Loss Shot)? Who Is It Suitable For? How Is It Used? What Are the Side Effects?”, we will examine the topic in detail. Semaglutide is a once-weekly injection used to support weight loss. It is prescribed for adults with obesity or excess weight. Common side effects include nausea and digestive system problems. Regular medical checkups are recommended while using this medication.

What Is Semaglutide?

Semaglutide supports weight loss and may also help maintain weight loss over time. It works by reducing appetite. It may be used to lower the risk of heart attack and stroke in people affected by excess weight. It can also be used in the treatment of liver disease caused by fat accumulation in the liver. Dietary and exercise changes are often recommended alongside this medication. This medicine may also be used for other purposes. Anyone with questions about its uses should consult a doctor or pharmacist.

What Should You Tell Your Doctor Before Using Semaglutide?

Before starting this medication, your doctor should know if any of the following conditions apply to you:
  • Diabetes.
  • Diabetes-related eye disease.
  • Gallbladder disease.
  • Current depression or a history of depression.
  • Current pancreatitis or a history of pancreatitis.
  • Planned surgery.
  • Kidney disease.
  • A personal or family history of a condition called MEN 2 (Multiple Endocrine Neoplasia Type 2), which causes tumors in endocrine glands.
  • A personal or family history of thyroid cancer.
  • Stomach or intestinal problems, such as difficulty digesting food.
  • Suicidal thoughts, suicide plans, or previous suicide attempts.
  • An unusual or allergic reaction to semaglutide, other medications, foods, dyes, or preservatives.
  • Pregnancy or plans to become pregnant.
  • Breastfeeding.

How Should Semaglutide Be Used?

This medication is injected under the skin. You will receive training on how to prepare and administer it correctly. It should be used exactly as directed on the prescription label. The injection is administered once a week (every 7 days). Continue using it unless your doctor instructs you to stop.
Used needles and injection pens should be disposed of in a designated sharps container. They should never be thrown into household trash. If you do not have a sharps container, ask your pharmacist or doctor how to obtain one.
A special medication guide will be provided by the pharmacist with each prescription and refill. This information should be read carefully every time.
This medicine is supplied with instructions for use. Ask your pharmacist if you need guidance on how to use it. Read all information carefully and consult your doctor or pharmacist if you have any questions. Talk to your doctor about the use of this medication in children. Although it may be prescribed in certain situations for children as young as 12 years old, special precautions may be necessary.
If you think you have taken too much of this medication, contact a poison control center or emergency department immediately.
This medication is prescribed only for the person named on the prescription and should not be shared with others.

What Should Be Done If a Dose Is Missed?

  • If a dose is missed and there are more than 2 days before the next scheduled dose, take the missed dose as soon as possible.
  • If a dose is missed and there are fewer than 2 days before the next scheduled dose, skip the missed dose and take the next dose at the regular time.
  • Do not take double doses or extra doses.
  • If doses have been missed for 2 weeks or longer, take the next dose at the regular time or consult your doctor about restarting the medication.

What Medications May Interact With Semaglutide?

Insulin and other medications used to treat diabetes.
This list may not include all possible interactions. Be sure to inform your doctor about all prescription medications, over-the-counter medicines, herbal products, and dietary supplements you use.
You should also tell your doctor if you smoke, drink alcohol, or use recreational drugs. Some substances may interact with this medication.

What Should Be Considered While Using Semaglutide?

Regular follow-up appointments with your doctor are important to monitor your progress. Inform your doctor if your condition does not improve or if it worsens.
If you are taking insulin or another diabetes medication, such as glipizide, tell your doctor. Combining these medications may increase the risk of low blood sugar. Be familiar with the signs of low blood sugar and how to manage it.
Discuss cancer risks with your doctor. The use of this medication may increase the risk of certain types of cancer. Contact your doctor immediately if you develop a lump or swelling in the neck, persistent hoarseness, difficulty swallowing, shortness of breath, or breathing problems.
Make sure to stay adequately hydrated while using this medication. Drink water frequently and consume fruits and vegetables with high water content. Increase your fluid intake during hot weather or periods of physical activity.
Contact your doctor immediately if you experience fever, infection, vomiting, diarrhea, or excessive sweating while taking this medication. Excessive fluid loss may make the use of this medication dangerous.
If you are scheduled for surgery or a medical procedure, inform your healthcare provider that you are taking semaglutide.
Do not use this medication if you are pregnant or may become pregnant without first consulting your doctor. Your healthcare provider can help determine the most appropriate option for you. Weight loss is generally not recommended during pregnancy.
Consult your doctor if you are breastfeeding. This medication may be used in certain situations, but its use during breastfeeding has not been adequately studied. Your doctor may recommend alternative options. 

What Are the Possible Side Effects of Semaglutide?

The following side effects should be reported to a doctor as soon as possible:
  • Allergic reactions: Skin rash, itching, hives, swelling of the face, lips, tongue, or throat.
  • Changes in vision.
  • Dehydration: Increased thirst, dry mouth, feeling faint or dizzy, headache, dark yellow or brown urine.
  • Fast or irregular heartbeat.
  • Gallbladder problems: Severe stomach pain, nausea, vomiting, fever.
  • Kidney injury: Reduced urination, swelling of the ankles, hands, or feet.
  • Pancreatitis: Severe stomach pain that may spread to the back or worsen after eating or when touched, fever, nausea, vomiting.
  • Mood changes: Thoughts of suicide or self-harm, worsening mood, feelings of depression.
  • Thyroid cancer: A new lump or mass in the neck, pain or difficulty swallowing, difficulty breathing, or hoarseness.
Side effects that generally do not require medical attention include:
  • Constipation.
  • Diarrhea.
  • Loss of appetite.
  • Nausea.
  • Stomach discomfort.
If these side effects persist or become bothersome, notify your doctor.
This may not be a complete list of all possible side effects. Contact your doctor for medical advice regarding side effects.

How Should Semaglutide Be Stored?

Keep this medication out of the reach of children and pets.

Refrigerated Storage (Preferred)

  • Store in a refrigerator.
  • Do not freeze.
  • Keep the medication in its original packaging until ready to use.
  • Discard any unused medication after the expiration date.

Room Temperature Storage

  • If necessary, the injection pen may be kept at room temperature for up to 28 days before removing the cap.
  • Protect it from light.
  • If stored at room temperature, discard any unused medication after 28 days or after the expiration date, whichever comes first.
When the medication is no longer needed or has expired, it is important to dispose of it properly as soon as possible. This can be done in one of the following ways:
  1. Take the medication to a drug take-back program. Ask your pharmacy or hospital if such a program is available.
  2. If the medication cannot be returned, follow the disposal instructions provided in the medication guide.
The information provided here is a summary and may not contain all possible details. Anyone with questions about this medication should consult a doctor or pharmacist.

Doctors in This Field

Specialist DietitianMerve BAHTIYAR
Private Medicabil Hospital
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DietitianBahar GUL
Private Yildirim Medicabil Hospital
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DietitianBegum DAG
Private Medicabil Hospital
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