Medicabil Logo
Blog Posts

Semaglutide Injection (Weight Loss Shot): What Is It? Who Is It For? How Is It Used? What Are Its Side Effects?

Created19.08.2026 11:51:00
·
Last Updated19.08.2026 11:52:03
·
Medical Review19.08.2026
·
·

Semaglutide Injection (Weight Loss Shot): What Is It? Who Is It For? How Is It Used? What Are Its Side Effects?

In this article, we will examine the details regarding this topic. Semaglutide is a weekly injection used to aid weight loss. It is intended for adults with obesity or those who are overweight. Common side effects include nausea and digestive issues. While using this medication, individuals should consult a physician for regular check-ups.

What Is Semaglutide?

Semaglutide promotes weight loss and can also help maintain weight loss. It works by reducing appetite. In individuals affected by excess weight, it may be used to reduce the risk of heart attack and stroke. Additionally, it can be used in the treatment of liver disease caused by fat accumulation in the liver. Diet and exercise modifications are frequently combined with this medication.

This medication may also be used for other purposes. Anyone with questions regarding this topic should consult a physician or pharmacist.

What Should You Tell Your Doctor Before Using Semaglutide?

Before starting this medication, your doctor needs to know if any of the following conditions are present:

  • Diabetes.
  • Diabetes-related eye disease.
  • Gallbladder disease.
  • Current depression or a history of depression.
  • Current pancreatitis or a history of pancreatitis.
  • Upcoming surgery.
  • Kidney disease.
  • Personal or family history of a condition called MEN 2, which causes tumors in the endocrine glands.
  • Personal or family history of thyroid cancer.
  • Stomach or intestinal problems, such as difficulty digesting food.
  • Suicidal thoughts, plans, or attempts.
  • An unusual or allergic reaction to semaglutide, other medications, foods, dyes, or preservatives.
  • Pregnancy or trying to become pregnant.
  • Breastfeeding.

How Should Semaglutide Be Used?

This medication is injected subcutaneously (under the skin). You will receive training on how to prepare and administer the medication. It should be used according to the instructions on the prescription label. It is administered once a week (every 7 days) and should be continued unless your doctor tells you to stop.

It is important to place used needles and pens in a special sharps container. They should not be thrown into the regular trash. If a sharps container is not available, consult a pharmacist or doctor to obtain one.

A special medication guide will be provided by the pharmacist with each prescription and refill. This information should be read carefully every time.

This medication comes with instructions for use. Information on how to use it should be obtained from a pharmacist, and instructions should be followed carefully. For any questions, consult a pharmacist or doctor.

Discuss the use of this medication in children with a doctor. Although it may be prescribed to children as young as 12 under certain circumstances, precautions must be applied.

If an overdose is suspected, contact a poison control center or emergency room immediately.

This medication is for the prescribed individual only and must not be shared with others.

What Should Be Done If a Dose Is Missed?

If a dose is missed and there are more than 2 days until the next scheduled dose, take the missed dose as soon as possible. If less than 2 days remain before the next scheduled dose, skip the missed dose and resume the regular schedule. Do not take a double or extra dose. If a dose is missed for 2 weeks or longer, take the next dose at the regular time or consult a doctor on how to restart the medication.

What Can Semaglutide Interact With?

  • Insulin and other medications used to treat diabetes.

This list may not include all possible interactions. Provide your doctor with a complete list of all medications, herbal products, over-the-counter drugs, or nutritional supplements being used. Inform your doctor about smoking, alcohol consumption, or any illegal drug use, as certain substances may interact with this medication.

What Should You Watch Out for While Using Semaglutide?

Consult your doctor regularly to evaluate the progress of your treatment. Inform your doctor if the condition does not improve or worsens.

Inform your doctor if taking medications for diabetes, such as insulin or glipizide, as this may increase the risk of low blood sugar (hypoglycemia). Learn the signs of low blood sugar and how to manage it.

Discuss cancer risks with your doctor, as the risk for certain types of cancer may be higher when using this medication. Contact your doctor immediately if a mass or swelling in the neck, persistent hoarseness, difficulty swallowing, or shortness of breath develops.

Ensure adequate fluid intake while using this medication by drinking water frequently and consuming fruits and vegetables with high water content. Increase water consumption during hot weather or physical activity. Contact a doctor immediately if fever, infection, vomiting, diarrhea, or excessive sweating occurs, as excessive fluid loss can make using this medication dangerous.

Inform your doctor if undergoing surgery or a medical procedure.

If pregnancy is possible or intended, do not use this medication without speaking to a doctor beforehand. Your doctor can help determine the appropriate option. Weight loss is not recommended during pregnancy.

Consult a doctor regarding breastfeeding. The medication may be used when advised, though its safety during breastfeeding has not been sufficiently studied, and alternative options may be suggested.

What Are the Potential Side Effects of Semaglutide?

Side effects that should be reported to a doctor as soon as possible include:

  • Allergic reactions: Skin rash, itching, hives, swelling of the face, lips, tongue, or throat.
  • Vision changes.
  • Dehydration: Increased thirst, dry mouth, feeling faint or dizzy, headache, dark yellow or brown urine.
  • Rapid or irregular heartbeat.
  • Gallbladder issues: Severe stomach pain, nausea, vomiting, fever.
  • Kidney damage: Decreased urination, swelling in the ankles, hands, or feet.
  • Pancreatitis: Severe stomach pain radiating to the back or worsening after eating or when touched, fever, nausea, vomiting.
  • Mood shifts: Thoughts of suicide or self-harm, worsening mood, feelings of depression.
  • Thyroid cancer: A new lump or mass in the neck, pain or difficulty swallowing, breathing difficulty, hoarseness.

Side effects that usually do not require medical attention include:

  • Constipation.
  • Diarrhea.
  • Loss of appetite.
  • Nausea.
  • Stomach discomfort.

If these side effects persist or become bothersome, report them to your doctor.

This list may not cover all possible side effects. Contact a doctor for medical advice regarding side effects.

How Should Semaglutide Be Stored?

Keep the medication out of reach of children and pets.

  • Refrigerated storage (preferred): Store in the refrigerator, but do not freeze. Keep the medication in its original packaging until ready to use. Discard any unused medication after the expiration date.
  • Room temperature storage: If necessary, the pen may be stored at room temperature for up to 28 days before removing the cap. Protect from light. If stored at room temperature, discard unused medication after 28 days or after the expiration date, whichever comes first.

Dispose of the medication properly and as soon as possible when no longer needed or expired. This can be done in two ways:

  • Take the medication to a drug take-back program. Consult a pharmacy or hospital to locate a disposal site.
  • If a take-back program is unavailable, follow the disposal instructions in the user manual.

The information provided here is a summary and may not contain all possible details. Anyone with questions about this medication should contact a doctor or pharmacist.